HOW SKYRIZI
WORKS
How does SKYRIZI work?
Plaque psoriasis on your skin actually starts inside your body. While the exact cause is unknown, an overactive immune system could be a source. SKYRIZI has been designed to work with your immune system, attaching to a specific protein that can cause inflammation. By attaching to this protein, SKYRIZI helps reduce the inflammation inside the body that leads to plaques on the skin.
How long do you spend managing your psoriasis symptoms every day?
How long do you spend managing your psoriasis symptoms every day?
This is how others answered:
Discussing how long you spend managing your symptoms can help your doctor understand your overall treatment goals and help you both make decisions about your treatment plan. If you want to get the conversation started and are looking for a dermatologist, you can start here.
SKYRIZI Works in the Immune System
SKYRIZI is a biologic designed to be similar to proteins found within your own immune system. It specifically attaches to a protein called IL-23, one of the proteins that may contribute to inflammation and plaque psoriasis.
The good and bad of inflammation
One of the ways your immune system protects you is with inflammation. However, too much inflammation can mean your immune system is overactive. That’s what happens with plaque psoriasis.
A protein imbalance
While the exact cause of plaque psoriasis is unknown, your body may produce too much of a protein called IL-23. IL-23 is one of several proteins that may contribute to excess inflammation inside the body, which can lead to painful, red, itchy, burning plaques on the skin.
What SKYRIZI does
This is where SKYRIZI comes in. SKYRIZI works by attaching to excess IL-23. This can help reduce the inflammation inside the body that leads to plaques on the skin.
Now that you know the science behind SKYRIZI treatment,
USE
SKYRIZI is a prescription medicine used to treat adults with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about SKYRIZI® (risankizumab-rzaa)?
SKYRIZI may cause serious side effects, including infections. SKYRIZI is a prescription medicine that may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with SKYRIZI and may treat you for TB before you begin treatment with SKYRIZI if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with SKYRIZI.
- Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:
- fever, sweats, or chills
- muscle aches
- weight loss
- cough
- warm, red, or painful skin or sores on your body different from your psoriasis
- diarrhea or stomach pain
- shortness of breath
- blood in your mucus (phlegm)
- burning when you urinate or urinating more often than normal
Before using SKYRIZI, tell your healthcare provider about all of your medical conditions, including if you:
- have any of the conditions or symptoms listed in the section “What is the most important information I should know about SKYRIZI?”
- have an infection that does not go away or that keeps coming back.
- have TB or have been in close contact with someone with TB.
- have recently received or are scheduled to receive an immunization (vaccine). Medications that interact with the immune system may increase your risk of getting an infection after receiving live vaccines. You should avoid receiving live vaccines right before, during, or right after treatment with SKYRIZI. Tell your healthcare provider that you are taking SKYRIZI before receiving a vaccine.
- are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of SKYRIZI?
SKYRIZI may cause serious side effects. See “What is the most important information I should know about SKYRIZI?”
The most common side effects of SKYRIZI include upper respiratory infections, feeling tired, fungal skin infections, headache, and injection site reactions.
These are not all the possible side effects of SKYRIZI. Call your doctor for medical advice about side effects.
Use SKYRIZI exactly as your healthcare provider tells you to use it.
SKYRIZI is available in a 150 mg/mL prefilled syringe and pen.
US-SKZD-210126
Please see the Full Prescribing Information, including the Medication Guide, for SKYRIZI.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie may be able to help.
Visit AbbVie.com/myAbbVieAssist to learn more.
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