SKYRIZI is a biologic designed to be similar to proteins found within your own immune system. It specifically attaches to a protein called IL-23, one of the proteins that may contribute to inflammation and plaque psoriasis.
The good and bad of inflammation
One of the ways your immune system protects you is with inflammation. However, too much inflammation can mean your immune system is overactive. That’s what happens with plaque psoriasis.
A protein imbalance
While the exact cause of plaque psoriasis is unknown, your body may produce too much of a protein called IL-23. IL-23 is one of several proteins that may contribute to excess inflammation inside the body, which can lead to painful, red, itchy, burning plaques on the skin.
What SKYRIZI does
This is where SKYRIZI comes in. SKYRIZI works by attaching to excess IL-23. This can help reduce the inflammation inside the body that leads to plaques on the skin.
Now that you know the science behind SKYRIZI treatment,
SKYRIZI is a prescription medicine used to treat adults with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).
SKYRIZI may cause serious side effects, including infections. SKYRIZI is a prescription medicine that may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with SKYRIZI and may treat you for TB before you begin treatment with SKYRIZI if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with SKYRIZI.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
SKYRIZI may cause serious side effects. See “What is the most important information I should know about SKYRIZI?”
The most common side effects of SKYRIZI include upper respiratory infections, fungal skin infections, headache, feeling tired, and injection site reactions.
These are not all the possible side effects of SKYRIZI. Call your doctor for medical advice about side effects.
Use SKYRIZI exactly as your healthcare provider tells you to use it.
US-RISN-180038
Please see the Full Prescribing Information, including the Medication Guide, for SKYRIZI.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit
or call 1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.
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