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1 injection, 4 times a year after 2 starter doses

SKYRIZI has 2 options designed around your needs for injecting: the SKYRIZI Pen and the single-dose prefilled syringe. Talk to your doctor about the options available to you.

Remember, your Skyrizi Complete Nurse Ambassador* is ready to answer your questions about how to inject properly. And help coach you through the process.

Have a question right now? Call your Nurse Ambassador at 1.866.SKYRIZI (1.866.759.7494).

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SKYRIZI Pen

Prefilled Syringe

Injecting with the SKYRIZI Pen

The SKYRIZI Pen helps you take your SKYRIZI with just one injection per treatment. Click the circles below to explore the Pen's features.

Hold down button to automatically inject medicine–it clicks when starting and stopping

Locking mechanism prevents you from starting injection accidentally

Large window gives clear view of medicine

Wide grip with rubber-lined sides make it easy to hold

Hold down button to automatically inject medicine–it clicks when starting and stopping

Locking mechanism prevents you from starting injection accidentally

Large window gives clear view of medicine

Wide grip with rubber-lined sides make it easy to hold

Watch this video on how to inject with the SKYRIZI Pen:

Transcript

A GUIDE TO INJECTING SKYRIZI

Hi, I’m Michael and I’m here to show you how to inject using a SKYRIZI Pen. I’ve been doing this for a while now, and I feel like I have a good handle on it.

My doctor showed me how to inject when I first started and I called Lauren (my Nurse Ambassador) and she helped me the first few times I did it at home by myself.

INJECTION PREP

Now, I get my SKYRIZI by mail and I keep it in the fridge until I’m ready to inject. There it is. There we go.

So, very important. I’ll leave it out at room temperature and out of direct sunlight for 30 to 90 minutes before injecting.

Now that I’ve washed and dried my hands, I’m good to go. So, I take out everything I need. I got my SKYRIZI Pen.

I’ve got the Instructions for Use for reference. I’ve also got an alcohol swab, a cotton ball, and my sharps container. So, I do my injections here because there’s just plenty of light and a lot of good space.

HOW TO INJECT STEP BY STEP

I like to think about the injection process like this. Pick, pull, place, push, and press.

So first, I’ll pick my injection site. I’m gonna go with my left thigh. But you can also inject into your stomach or your other thigh.

If you choose your stomach, make sure that you inject at least 2 inches away from your belly button.

Grab your alcohol swab and clean your skin in a circular motion like this, and let it dry.

Now, I hold the Pen with the dark gray cap pointing up. I pull the cap straight off and throw it away.

Now I check the liquid through the inspection window. It should look clear to slightly yellow and may contain tiny white or clear particles. It’s normal to see one or more bubbles in the liquid.

So, I hold my Pen with my fingers on the gray grips. See? And I turn the Pen so that the white needle sleeve points toward my injection site and I can see the green activator button.

I also make sure that I can clearly see the inspection window while I’m injecting.

I gently squeeze my skin at my injection site and make a raised area and hold it firmly. Then I place the white needle sleeve straight against the raised area, at a 90 degree angle, and push the Pen down against my skin. Throughout the process, I keep pinching the raised area and keep steady pressure against it.

Now I can see the green activator button and inspection window. The Pen only activates if the white needle sleeve is pressed firmly down against me before pressing the green activator button. A loud “click” means the start of the injection. There it goes.

And hold it like that for 15 seconds. Now, I’ll keep pushing the Pen down against my skin until I hear a second “click” or the yellow indicator has filled the inspection window—either one signals the injection is complete. And there it goes.

I check to make sure that the yellow indicator is fully down to be sure the injection is complete. Only then do

I slowly pull the pen straight out from my skin. You might notice one last click. And look at this - you see how the white needle sleeve covers the needle tip?

And that’s it. Now, I press a cotton ball where I injected - you could also use a gauze pad.

And I drop my used Pen in one of these Sharps Disposal Containers.

There - safe and sound, and also out of reach. Another injection complete!

HELPFUL TIPS FOR SELF-INJECTING

To recap, I prepare myself and my space. Pick an injection site, pull the cap off the Pen, place the Pen on the injection site, push the Pen firmly down against my skin, press the button to inject, and keep steady pressure on the injection site for the full 15 seconds.

Then safely discard the used Pen. That’s the whole injection process!

When I started injecting at home, it didn’t take me long to get it down. Lauren, my Nurse Ambassador, she suggested I create a routine - inject at the same time and place.

I also like to treat myself after each injection and maybe I’ll cycle or listen to a new album.

And this Skyrizi Complete App helps me stay on track, and I don’t know what I’d do without it.

I used it to log my first starter dose, so I knew when to take my second starter dose 4 weeks later.

And you can set reminders for future doses, too, since after 2 starter doses, SKYRIZI is only 1 injection, 4 times a year.

And when I get those reminders, I know to contact my specialty pharmacy to get my next injection on time.

And don’t forget about the Skyrizi Complete Sharps Disposal and mail-back service. I signed up online, so once my Sharps Container gets full, I request a new one, which is sent to me with a box to send my full one back. It’s so convenient, and it doesn’t cost me anything.

And I’m lucky that my family’s always around if I need help. I’ve got Skyrizi Complete, too. Like Lauren, who has answers to my questions and a pretty awesome app!

You’ve got this.

Looking for specific injection information?

Taking your SKYRIZI injection in 4 steps

A simple way to remember how to inject is with “4 P’s”:

Pick the injection site
Pull the cap off
Place Pen on site
Press the button

1. Pick the injection site

Choose where you’re most comfortable with your injection:

In the front of either thigh or in your stomach, at least 2 inches from your belly button

Once you wash and dry your hands:

Settle into a relaxed place
Wipe the injection site in a circular motion with the alcohol swab
Let it dry

A few things to look out for:

DO NOT touch or blow on the injection site after it is cleaned.
Allow the skin to dry before injecting
DO NOT inject through clothes
DO NOT inject into skin that is sore, bruised, red, hard, scarred, has stretch marks, or areas with psoriasis

2. Pull the cap off

Hold the Pen with the dark gray cap pointing up
Pull the dark gray cap straight off
Throw the dark gray cap away

Check the liquid through the inspection window

It is normal to see one or more bubbles in the liquid
The liquid should look clear to yellow and may contain tiny white or clear particles
DO NOT use if the liquid is cloudy or contains flakes or large particles

3. Place Pen on site

Hold the Pen with your fingers on the gray hand grips
Turn the Pen so that the white needle sleeve points toward the injection site and you can see the green activator button
Gently squeeze the skin at your injection site to make a raised area and hold it firmly
Place the white needle sleeve straight (90° angle) against the raised injection site

4. Press the button

Hold the Pen so that you can see the green activator button and inspection window
Push and keep pressing the Pen down against the pinched skin

The Pen will activate only if the white needle sleeve is pressed down.

Press the green activator button and hold the Pen for 15 seconds

A loud “click” means the start of the injection.

Keep pressing the Pen down against the injection site

The injection is complete when:

the Pen has made a second “click”

the yellow indicator has filled the inspection window

This takes up to 15 seconds.

When the injection is complete

Slowly pull the Pen straight out from the skin

After completing the injection

Place a cotton ball or gauze pad on the skin at the injection site

The white needle sleeve will cover the needle tip and make another “click.”

A few things to know:

DO NOT rub the injection site
Slight bleeding at the injection site is normal

Dispose of your Pen in a sharps disposal container.

Need a sharps container?
Skyrizi Complete can deliver one right to your door at no cost to you. Sign up or log in to access your Skyrizi Complete resources and order your container today.

SKYRIZI pen disposed in a sharps container

Remember—do not throw your Pens away in the household trash. When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of it. There may be state or local laws about how you should throw away used needles and syringes.

For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: www.fda.gov/safesharpsdisposal

Want to prepare for your next injection? You can set reminders and log injections on the Skyrizi Complete App.

Download here:

Want to prepare for your next injection? You can set reminders and log injections on the Skyrizi Complete App.

Don’t have the App? Download here.

Want to prepare for your next injection? You can set reminders and log injections on the Skyrizi Complete App.

4 quick tips for injecting

This guide can help give you a refresher on helpful tips for injecting.
You can print it out or save it for your next injection.
Check it out here

Injecting with the SKYRIZI single-dose prefilled syringe

The single-dose prefilled syringe takes one injection per treatment. Click the circles below to explore the syringe’s features.

Self-guided plunger lets you activate and control the injection

You control the duration of your injection

Finger grips to help hold the syringe while injecting

Guard comes over the needle to let you know injection is finished

Finger grips to help hold the syringe while injecting

You control the duration of your injection

Self-guided plunger lets you activate and control the injection

Does your prescribed treatment call for injecting with 2 syringes, 4 times a year?

Check the box your SKYRIZI arrived in to see if it says "75mg". If it does, learn how to inject here

If your box says "150mg", the injection information for the single-dose syringe is below.