SKYRIZI injection support

On this page:

SKYRIZI Pen

Prefilled Syringe

Injection Support

Treatment Schedule

Skyrizi Complete App

1 injection, 4 times a year after 2 starter doses

SKYRIZI has 2 options designed around your needs for injecting: the SKYRIZI Pen and the single-dose prefilled syringe. Talk to your doctor about the options available to you.

Remember, your Skyrizi Complete Nurse Ambassador* is ready to answer your questions about how to inject properly. And help coach you through the process after you’ve been trained by your healthcare professional.

Have a question right now? Call your Nurse Ambassador at 1.866.SKYRIZI (1.866.759.7494).

Need help reviewing insurance
coverage options?

This comparison chart can help ▸

Support for adults with moderate to severe Crohn's disease

SKYRIZI infusion support

SKYRIZI On-Body Injector support

Injecting with the SKYRIZI Pen

The SKYRIZI Pen helps you take SKYRIZI with one injection per treatment. Use the link below to learn more about the Pen and to:

Get a refresher on how to inject
Get specific injection information
Discover quick tips for injecting

Read the Instructions for Use before you start using SKYRIZI and each time you get a refill.

Use the circles below to explore the Pen’s features.

Hold down button to automatically inject medicine–it clicks when starting and stopping

Locking mechanism prevents you from starting injection accidentally

Large window gives clear view of medicine

Wide grip with rubber-lined sides helps with holding the Pen

Watch, step-by-step, how to inject with the SKYRIZI Pen:

Transcript

Watch the full video. Then choose a specific step from the menu above to watch any of the sections again.

SUPER/VOICEOVER (V.O.):

This demonstration is a guide to injecting with the SKYRIZI Pen.

Watch it and also read the entire SKYRIZI Instructions for Use leaflet, inserted with your medication package.

Don’t try to inject SKYRIZI until your doctor has decided you can, and you’ve been shown the right way to inject.

SUPER:

[SKYRIZI logo]

Please see Use and Important Safety Information at the end of this video.

Please see link for the full Prescribing Information, including the Medication Guide, for SKYRIZI.

SUPER/V.O.:

SKYRIZI® (risankizumab-rzaa) USES

SKYRIZI is a prescription medicine used to treat adults:

with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).
with active psoriatic arthritis (PsA).

SAFETY CONSIDERATIONS
SKYRIZI may cause serious side effects, including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help right away if you get any symptoms of a serious allergic reaction.

Infections: SKYRIZI may increase your risk of infections. Before starting treatment, your doctor should check you for infections and tuberculosis. Tell your doctor right away if you have an infection or symptoms of one.

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the ingredients in SKYRIZI.

Also, tell your doctor if you plan to or recently received a vaccine.

SUPER:

A GUIDE TO INJECTING WITH SKYRIZI

PATIENT V.O.:

Hi, I’m Michael. And I’m here to show you how to inject using a SKYRIZI Pen.

SUPER:

MICHAEL

PATIENT V.O.:

I’ve been doing this for a while now, and I feel like I have a good handle on it. Ah, my doctor showed me how to inject when I first started. And I called Lauren (my Nurse Ambassador) and she helped me the first few times I did it at home by myself.

SUPER:

Don’t have a Nurse Ambassador?* Call 1.866.SKYRIZI or visit www.SKYRIZI.com

* Nurse Ambassadors are provided by AbbVie and do not work under the direction of your health care professional (HCP) or give medical advice. They are trained to direct patients to their HCP for treatment-related advice, including further referrals.

SUPER:

INJECTION PREP

PATIENT V.O.:

Now, I get my SKYRIZI by mail and I keep it in the fridge until I’m ready to inject. Ah, there it is. There we go.

SUPER:

Do not warm SKYRIZI in any other way (for example, do not warm it in a microwave or in hot water).

PATIENT V.O.:

So, very important. I’ll leave it out at room temperature and out of direct sunlight for 30 to 90 minutes before injecting.

SUPER:

Do not use SKYRIZI if liquid has been frozen even if it has been thawed.
30 to 90 minutes.

Keep SKYRIZI in the original carton to protect from light until time to use.

PATIENT V.O.:

Now that I’ve washed and dried my hands, I’m good to go.

SUPER:

Do not shake SKYRIZI.

Do not use if the SKYRIZI Pen has been dropped or damaged.

Do not use SKYRIZI if package perforations are broken. Return product to the pharmacy.

Do not remove the dark gray cap until right before injection.

PATIENT V.O.:

So, I take out everything I need: Ah, I got my SKYRIZI Pen. I’ve got the Instructions for Use for reference. I’ve also got an alcohol swab, a cotton ball, and my Sharps container.

SUPER:

SKYRIZI PEN

INSTRUCTIONS FOR USE

ALCOHOL SWAB

Not included in your package

COTTON BALL

Not included in your package

SHARPS CONTAINER

PATIENT V.O.:

So, I do my injections here because there’s just plenty of light and a lot of good space.

SUPER:

Do not use SKYRIZI if expiration date (EXP) has passed.

SUPER:

HOW TO INJECT step-by-step

PATIENT V.O.:

I like to think about the injection process like this…Pick. Pull. Place. Push. And press. So first...

SUPER:

PICK the injection site

PATIENT V.O.:

I’ll pick my injection site. I’m gonna go with my left thigh. But you can also inject into your stomach or your other thigh. If you choose your stomach, make sure that you inject at least two inches away from your belly button.

SUPER:

2 INCHES

PATIENT V.O.:

Grab your alcohol swab and clean your skin in a circular motion like this. And let it dry.

SUPER:

Do not touch or blow on the injection site after it is cleaned. Allow the skin to dry before injecting.

PATIENT V.O.:

Now, I hold the Pen with the dark gray cap pointing up. I pull the cap straight off and throw it away.

SUPER:

PULL the cap off

Do not inject through clothes.

Do not inject into skin that is sore, bruised, red, hard, scarred, has stretch marks, or areas with psoriasis.

PATIENT V.O.:

Now I check the liquid through the inspection window. It should look clear to slightly yellow and may contain tiny white or clear particles. It’s normal to see one or more bubbles in the liquid.

SUPER:

Do not use if the liquid is cloudy or contains flakes or large particles.

PATIENT V.O.:

So, I hold my Pen with my fingers on the gray grips. See? And I turn the Pen so that the white needle sleeve points toward my injection site and I can see the green activator button.

SUPER:

NEEDLE SLEEVE

PATIENT V.O.:

I also make sure that I can clearly see the inspection window while I’m injecting.

I gently squeeze my skin at my injection site and make a raised area and hold it firmly. Then I place the white needle sleeve straight against the raised area, at a 90-degree angle, and push the Pen down against my skin.

SUPER:

PLACE 90°
& PUSH against skin

PATIENT V.O.:

Throughout the process, I keep pinching the raised area and keep steady pressure against it.
Now I can see the green activator button and inspection window. The Pen only activates if the white needle sleeve is pressed firmly down against me before pressing the green activator button.

SUPER:

PUSH against skin
The Pen will activate only if the white needle sleeve is firmly pushed down against the injection site before pressing the green activator button.

PATIENT V.O.:

A loud click means the start of the injection. There it goes.

SUPER:

PRESS the green button and keep steady pressure

Circle counting down from 15 to 0

PATIENT V.O.:

And hold it like that for 15 seconds. Now, I’ll keep pressing the Pen down against my skin until I hear a second click or the yellow indicator has filled the inspection window–either one signals the injection is complete. And there it goes. I check to make sure that the yellow indicator is fully down to be sure the injection is complete. Only then do I slowly pull the pen straight out from my skin.
You might notice one last click. And look at this. You see how the white needle sleeve covers the needle tip?
And that’s it! Now I press a cotton ball where I injected. You could also use a gauze pad.

SUPER:

Press a cotton ball or gauze pad over the injection site and hold for 10 seconds. Do not rub the injection site. You may have slight bleeding. This is normal.

PATIENT V.O.:

And I drop my used Pen in one of these Sharps Disposal Containers.

SUPER:

Your Skyrizi Complete Sharps Disposal Container may look a little different than the one shown.

PATIENT V.O.:

There. Safe and sound and also out of reach. Another injection complete.

SUPER:

HELPFUL TIPS for self-injecting

PATIENT V.O.:

To recap, I prepare myself and my space. Pick an injection site. Pull the cap off the Pen. Place the Pen on the injection site. Push the Pen firmly down against my skin. Press the button to inject. And keep steady pressure on the injection site for the full 15 seconds.

Then safely discard the used Pen. That’s the whole injection process.

SUPER:

PICK the injection site

PULL the cap off

PLACE Pen on site

PUSH firmly down against skin

PRESS the button

DISCARD used Pen

PATIENT V.O.:

When I started injecting at home, it didn’t take me long to get it down. Lauren, my Nurse Ambassador, she suggested I create a routine. Inject at the same time and place. I also like to treat myself after each injection. And maybe I’ll cycle or listen to a new album.

And this Skyrizi Complete App helps me stay on track, and I don’t know what I’d do without it. I used it to log my first starter dose, so I knew when to take my second starter dose four weeks later.

And you can set reminders for future doses, too, since, after two starter doses, SKYRIZI is only 1 injection, 4 times a year.

SUPER:

1 INJECTION

4x A YEAR

PATIENT V.O.:

And when I get those reminders, I know to contact my specialty pharmacy to get my next injection on time.

And don’t forget about the Skyrizi Complete Sharps Disposal and mail-back service. I signed up online, so once my Sharps Container gets full, I request a new one. Which is sent to me with a box to send my full one back. It’s so convenient, and it doesn’t cost me anything.

SUPER:

Get sharps containers for no additional cost at www.SKYRIZI.com or call 1.866.SKYRIZI

PATIENT V.O.:

And I’m lucky that my family’s always around if I need help. I’ve got Skyrizi Complete, too. Like Lauren, who has answers to my questions, and a pretty awesome App.

SUPER:

CALL 1.866.SKYRIZI

FOR 24/7 SUPPORT WITH SKYRIZI COMPLETE

PATIENT V.O.:

You’ve got this.

SUPER/V.O.:

USES AND IMPORTANT SAFETY INFORMATION¹

SKYRIZI® (risankizumab-rzaa) USES

SKYRIZI is a prescription medicine used to treat adults:

with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy).
with active psoriatic arthritis (PsA).

IMPORTANT SAFETY INFORMATION
What is the most important information I should know about SKYRIZI ^® (risankizumab-rzaa)?

SKYRIZI is a prescription medicine that may cause serious side effects, including: 

Serious allergic reactions: 

Stop using SKYRIZI and get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction: 
-  fainting, dizziness, feeling lightheaded (low blood pressure)
-  swelling of your face, eyelids, lips, mouth, tongue, or throat
-   trouble breathing or throat tightness
-  chest tightness
-  skin rash, hives
-  itching

Infections:
SKYRIZI may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with SKYRIZI and may treat you for TB before you begin treatment with SKYRIZI if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with SKYRIZI.

 Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:
- fever, sweats, or chills
- cough
- shortness of breath
- blood in your mucus (phlegm)
- muscle aches
- warm, red, or painful skin or sores on your body different from your psoriasis 
- weight loss
- diarrhea or stomach pain
- burning when you urinate or urinating more often than normal

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the ingredients in SKYRIZI. See the Medication Guide or Consumer Brief Summary for a complete list of ingredients.

Before using SKYRIZI, tell your healthcare provider about all of your medical conditions, including if you:

have any of the conditions or symptoms listed in the section “What is the most important information I should know about SKYRIZI?”
have an infection that does not go away or that keeps coming back.
have TB or have been in close contact with someone with TB.
have recently received or are scheduled to receive an immunization (vaccine). Medications that interact with the immune system may increase your risk of getting an infection after receiving live vaccines. You should avoid receiving live vaccines right before, during, or right after treatment with SKYRIZI. Tell your healthcare provider that you are taking SKYRIZI before receiving a vaccine.
are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm your unborn baby.
are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes into your breast milk.
become pregnant while taking SKYRIZI. You are encouraged to enroll in the Pregnancy Registry, which is used to collect information about the health of you and your baby. Talk to your healthcare provider or call 1-877-302-2161 to enroll in this registry.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of SKYRIZI?
SKYRIZI may cause serious side effects. See “What is the most important information I should know about SKYRIZI?”

The most common side effects of SKYRIZI in people treated for plaque psoriasis and psoriatic arthritis include: upper respiratory infections, headache, feeling tired, injection site reactions, and fungal skin infections.

These are not all the possible side effects of SKYRIZI. Call your doctor for medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

SKYRIZI is available in a 150 mg/mL prefilled syringe and pen.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

SUPER:

Reference: 1. SKYRIZI [package insert]. North Chicago, IL: AbbVie Inc.

US-SKZD-220756

[SKYRIZI logo]

SUPER/V.O.:

Please see link for the full Prescribing Information, including the Medication Guide, for SKYRIZI.

Close transcript

Looking for specific injection information?

Taking your SKYRIZI injection in 4 steps

A simple way to remember how to inject is with “4 P’s”:

Quick Links

1. Pick the injection site

2. Pull the cap off

3. Place Pen on site

4. Press the button

1. Pick the injection site

Person choosing their thigh as the injection site

Person choosing their stomach as the injection site

Choose where you’re most comfortable with your injection:

In the front of either thigh or in your stomach, at least 2 inches from your belly button

Once you wash and dry your hands:

Settle into a relaxed place
Wipe the injection site in a circular motion with the alcohol swab
Let it dry

A few things to look out for:

DO NOT touch or blow on the injection site after it is cleaned.
Allow the skin to dry before injecting
DO NOT inject through clothes
DO NOT inject into skin that is sore, bruised, red, hard, scarred, has stretch marks, or areas with psoriasis

2. Pull the cap off

Person removing the cap from a skyrizi pen

Hold the Pen with the dark gray cap pointing up
Pull the dark gray cap straight off
Throw the dark gray cap away

Close-up of the skyrizi pen inspection window

Check the liquid through the inspection window

It is normal to see one or more bubbles in the liquid
The liquid should look clear to yellow and may contain tiny white or clear particles
DO NOT use if the liquid is cloudy or contains flakes or large particles

3. Place Pen on site

Hold the Pen with your fingers on the gray hand grips
Turn the Pen so that the white needle sleeve points toward the injection site and you can see the green activator button
Gently squeeze the skin at your injection site to make a raised area and hold it firmly
Place the white needle sleeve straight (90° angle) against the raised injection site

4. Press the button

Hold the Pen so that you can see the green activator button and inspection window
Push and keep pressing the Pen down against the pinched skin

The Pen will activate only if the white needle sleeve is pressed down.

Press the green activator button and hold the Pen for 15 seconds

A loud “click” means the start of the injection.

Keep pressing the Pen down against the injection site

Close-up of the yellow indicator in the skyrizi pen inspection window

The injection is complete when:

the Pen has made a second “click”

the yellow indicator has filled the inspection window

Person pressing a cotton ball on the injection site

This takes up to 15 seconds.

When the injection is complete

Slowly pull the Pen straight out from the skin

After completing the injection

Place a cotton ball or gauze pad on the skin at the injection site

The white needle sleeve will cover the needle tip and make another “click.”

A few things to know:

DO NOT rub the injection site
Slight bleeding at the injection site is normal

4 quick tips for injecting

This guide can help give you a refresher on helpful tips for injecting.
You can print it out or save it for your next injection.

Download tips for injecting at home ►

Close

Injecting with the SKYRIZI single-dose prefilled syringe

The single-dose prefilled syringe helps you take SKYRIZI with one injection per treatment. Use the link below to learn more about the syringe and to:

Get a refresher on how to inject
Get specific injection information
Discover quick tips for injecting

Read the Instructions for Use before you start using SKYRIZI and each time you get a refill.

Use the circles below to explore the syringe’s features.

Self-guided plunger lets you activate and control the injection

You control the duration of your injection

Finger grips to help hold the syringe while injecting

Guard comes over the needle to let you know injection is finished

Watch, step-by-step, how to inject SKYRIZI with a syringe:

Transcript

SUPER/VOICEOVER (V.O.):

This demonstration is a guide to injecting with the SKYRIZI prefilled syringe.

Watch it and also read the entire SKYRIZI Instructions for Use leaflet, inserted with your medication package.

Don’t try to inject SKYRIZI until your doctor has decided you can, and you’ve been shown the right way to inject.

SUPER:

[SKYRIZI logo]

Please see Instructions for Use and Important Safety Information within the website.

Please see accompanying full Prescribing Information, including Medication Guide, and discuss with your doctor.

SUPER:

A GUIDE TO INJECTING SKYRIZI

MAYA

PATIENT V.O.:

Hey there! I’m Maya and I’m here to walk you through how to inject yourself with SKYRIZI. Now, if it’s your first time, don’t worry! If it’s not your first time, I hope you pick up some new tips while you’re here.

Now, I’ve done this a few times by myself, but my doctor originally walked me through how to inject, and I called Bryan, who’s my Nurse Ambassador, when I first started injecting on my own at home.

SUPER:

Don’t have a Nurse Ambassador?* Call 1.866.SKYRIZI or visit www.SKYRIZI.com

SUPER:

INJECTION PREP

PATIENT V.O.:

Alright, let’s get started. So, when my SKYRIZI comes in the mail, it goes straight in the fridge. Now, before I inject, I let it sit out for 15 to 30 minutes, out of direct sunlight, to get to room temperature. And while I wait, I try to relax.

SUPER:

Do not warm SKYRIZI in any other way (for example, do not warm it in a microwave or in hot water).

Do not use SKYRIZI if liquid has been frozen even if it has been thawed.
15 to 30 minutes
Keep SKYRIZI in the original carton to protect from light until time to use.

PATIENT V.O.:

Okay, that should be enough time.

SUPER:

Do not shake SKYRIZI.

Do not use SKYRIZI if the syringe has been dropped or damaged.

Do not use SKYRIZI if package perforations are broken. Return product to the pharmacy.

Do not remove the needle cover until right before the injection.

Do not use SKYRIZI if expiration date (EXP) has passed.

PATIENT V.O.:

So, once my hands are clean, I like to put out everything that I’ll need. So, I have my SKYRIZI syringe. I have an alcohol swab, which I got from my local pharmacy. I also have the Instructions for Use, just in case. I like to grab a cotton ball (I had some right in my medicine cabinet) and then a sharps container.

SUPER:

SKYRIZI SYRINGE with cardboard sleeve removed

ALCOHOL SWAB not included in your package

INSTRUCTIONS FOR USE

COTTON BALL not included in your package

SHARPS CONTAINER

Now, I like this spot because there’s a lot of space, and I don’t have to leave my couch.

SUPER:

CHAPTER 3: HOW TO INJECT step-by-step

SUPER:

So, it helps me to break down the injection process into 4 simple steps: the 4 P’s. And you can see them here on the package. We have: pick, prepare, pinch, push. Okay?

So, first I pick my injection site.

SUPER:

PICK the injection site

PATIENT V.O.:

So, I’ll go with my left thigh. But, you can also pick your right thigh or your lower stomach.

But, if you choose your stomach, make sure to inject at least 2 inches away from your belly button. Okay?

SUPER:

2 INCHES

PATIENT V.O.:

So, you want to grab your alcohol swab to clean your skin in a circular motion, like this, okay, and let it dry.

SUPER:

Do not touch or blow on the injection site after it is cleaned. Allow the skin to dry before injecting.

Remove prefilled syringe from cardboard sleeve by holding the finger grip.

Do not hold or pull plunger rod when removing the prefilled syringe from the sleeve.

Do not inject through clothes.

Do not inject into skin that is sore, bruised, red, hard, scarred, or has stretch marks.

Do not use if the liquid is cloudy or contains flakes or large particles.

PATIENT V.O.:

Now, I hold my syringe with the needle facing down, and I check the liquid inside to make sure that everything looks okay. So, it should be clear to slightly yellow, which it is. See that? And there’s a few bubbles in there, but that’s normal. So looks like we’re good to go!

Alright, so I hold my syringe in one hand, and I take the needle cover off with the other hand. Okay?

SUPER:

PREPARE the syringe

Do not hold or pull plunger when removing the needle cover.

Do not touch the needle with your fingers or let the needle touch anything.

PATIENT V.O.:

Like this, and then you want to throw it away. You see? You may see a drop of liquid at the end of the needle, which is normal. Okay?.

So, I’ve got my syringe in one hand, and with the other hand, I’m gently pinching the area of my cleaned skin to hold firmly.

SUPER

PINCH the skin

PATIENT V.O.:

Now I’ll inject the needle into my skin at about a 45-degree angle using a quick, short movement–like this.

SUPER:

PUSH the plunger in

45°

PATIENT V.O.:

Now, holding the angle steady, I slowly push the plunger in all the way until all of the liquid is injected, and the syringe is empty. There we go.

Now, I pull the needle out of my skin while keeping the syringe at the same angle, like this, and I release the plunger to allow the syringe to move up... until the entire needle is covered up by the needle guard. See how that works? The needle guard won’t come back down unless all the liquid has been injected.

SUPER:

Press a cotton ball or gauze pad over the injection site and hold for 10 seconds.

Do not rub the injection site. You may have slight bleeding. This is normal.

PATIENT V.O.:

Alright, so now, I press my cotton ball where I just injected, and that’s it!

I drop my used syringe in one of these handy sharps disposal containers and—voila—safe and sound.

SUPER:

Your Skyrizi Complete Sharps Disposal Container may look a little different than the one shown.

PATIENT V.O.:

Now I’ll just put it back out of reach. And just like that, another injection complete!

SUPER:

HELPFUL TIPS for self-injecting

PATIENT V.O.:

So, to recap, I prepare myself and my space. I pick an injection site, prepare the syringe, pinch the skin, push the plunger in.

SUPER:

PICK the injection site

PREPARE the syringe

PINCH the skin

PUSH the plunger in

PATIENT V.O.:

And safely discard the syringe. That’s the whole injection process!

Now, it seemed tricky at first, but I got it down soon enough. And Bryan, my Nurse Ambassador, he recommended I create a routine–injecting at the same time, same place–that sort of thing. I also do something nice for myself after each injection–maybe I’ll paint as a reward.

Oh, and this Skyrizi Complete App has helped me so much.

I mean, I used it to log my first starter dose so I knew when to take my second starter dose 4 weeks later. You can set reminders for future doses, too since, after 2 starter doses, SKYRIZI is only 1 injection, 4 times a year.

SUPER:

1 INJECTION

4x A YEAR

PATIENT V.O.:

And when I get those reminders, I know to contact my specialty pharmacy to get my next injection on time.

Oh, and I can’t forget about the Skyrizi Complete sharps disposal and mail-back service.

SUPER:

Get sharps containers for no additional cost at www.SKYRIZI.com or call 1.866.SKYRIZI

Image: The word “FULL” superimposed on an image of a sharps container

PATIENT V.O.:

Once my sharps container gets full, I request a new one that’s sent to me with a box to mail this one back. I signed up for the service online, and it doesn’t cost me anything!

I’m lucky to have people around to support me. I’ve got Skyrizi Complete on my team, too. Like Bryan, who’s such a good listener, and this App!

SUPER:

CALL 1.866.SKYRIZI

FOR 24/7 SUPPORT WITH SKYRIZI COMPLETE

PATIENT V.O.:

There’s always someone to reach out to if you need help. You’ve got this.

SUPER/V.O.:

SAFETY CONSIDERATIONS¹

SKYRIZI may cause serious side effects, including:

Serious allergic reactions: Stop using SKYRIZI and get emergency medical help right away if you get any symptoms of a serious allergic reaction.
Infections: SKYRIZI may increase your risk of infections. Before starting treatment, your doctor should check you for infections and tuberculosis. Tell your doctor right away if you have an infection or symptoms of one.

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the ingredients in SKYRIZI.

Also, tell your doctor if you plan to or recently received a vaccine.

SUPER:

Reference: 1. SKYRIZI [package insert]. North Chicago, IL: AbbVie Inc.

SUPER/V.O.:

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

SUPER:

US-SKZ-220107

[SKYRIZI logo]

Please see Use and Important Safety Information within the website.

Please see accompanying full Prescribing Information, including Medication Guide, and discuss with your doctor.

Close transcript

Looking for specific injection information?

Taking your SKYRIZI injection in 4 steps

A simple way to remember how to inject is with “4 P’s”:

Quick Links

1. Pick the injection site

2. Prepare the syringe

3. Pinch the skin

4. Push the plunger in

1. Pick the injection site

An image of 2 injection sites: the stomach and the thigh

Choose where you’re most comfortable with your injection:

In the front of either thigh or in your stomach, at least 2 inches from your belly button

Once you wash and dry your hands:

Settle into a relaxed place
Wipe the injection site in a circular motion with an alcohol swab before injecting

Do not touch or blow on the injection site after it is cleaned.

Allow the skin to dry before injecting

A few things to look out for:

DO NOT inject through your clothes
DO NOT inject into skin that’s bruised, red, sore, scarred, hard, has stretch marks, or is affected by psoriasis
DO NOT use SKYRIZI if the expiration date has passed
DO NOT use SKYRIZI if liquid has been frozen, even if it has been thawed

2. Prepare the syringe

Hold the syringe with the covered needle facing down
The liquid in the syringe should look clear to slightly yellow and may contain tiny white or clear particles. It is normal to see 1 or 2 bubbles
Hold the syringe in 1 hand and gently pull the needle cover straight off with the other. Then throw it away

It’s normal to see a drop of fluid on the needle point

A few things to look out for:

DO NOT use the prefilled syringe if the liquid is cloudy or has large particles or flakes
DO NOT hold or pull the plunger when removing the needle cover

Remember not to touch the needle with your fingers or let the needle touch anything.

3. Pinch the skin

Hold the body of the syringe in 1 hand, between the thumb and index finger
With the other hand, gently pinch the area of cleaned skin and hold it
Insert the needle at a 45-degree angle with a quick, short movement. Hold the angle steady

Something to look out for:

DO NOT touch the needle with your fingers or let the needle touch anything

4. Push the plunger in

Person pushing the plunger on the skyrizi syringe

Slowly push the plunger all the way down until all of the liquid is injected and the syringe is empty
Gently pull the needle out of the skin while keeping the syringe at the same angle
Release the plunger and allow the syringe to move up until the entire needle is covered by the needle guard

Person pressing a cotton swap to their skin

The syringe needle guard will not activate unless all the liquid has been injected.

Press a cotton ball or gauze pad over your injection site for 10 seconds

Something to look out for:

DO NOT rub the injection site.
It’s normal to have some bleeding

4 quick tips for injecting

This guide can help give you a refresher on helpful tips for injecting.
You can print it out or save it for your next injection.

Download tips for injecting at home ►

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Your Nurse Ambassador is here to help

Whether you're just getting the hang of injecting or could use a refresher, your Nurse Ambassador is here to help. At no cost to you, they offer step-by-step injection training after you've been shown how to inject by your healthcare professional. They can also help you access what you'll need to start and stay on track with your prescribed treatment plan.

Need help now?

Call your dedicated Nurse Ambassador at 1.866.SKYRIZI (1.866.759.7494).

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^*Nurse Ambassadors are provided by AbbVie and do not work under the direction of your health care professional (HCP) or give medical advice. They are trained to direct patients to their HCP for treatment-related advice, including further referrals.