What is SKYRIZI?

SKYRIZI is a biologic prescription for adults with moderate to severe plaque psoriasis and for adults with active psoriatic arthritis.

SKYRIZI (Sky-RIZZ-ee; skaɪ rɪz zi) is an interleukin-23 (IL-23) inhibitor that works inside the body to treat adults with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy) and for adults with active psoriatic arthritis. The exact cause of plaque psoriasis and psoriatic arthritis are unknown.

Talk to your doctor to see if SKYRIZI may be right for you.

Ask yourself:

  • Do you feel soreness or pain in your joints?
  • Do you feel stiffness and swelling in your joints? If so, where?
  • Are you having trouble standing or gripping?

If you answered yes, you could be experiencing symptoms of psoriatic arthritis (PsA). Ask your doctor if SKYRIZI may be right for you.

Dosing with SKYRIZI

2 starter doses-4 weeks apart. Continue with 1 does every 12 weeks.

SKYRIZI is 1 dose, 4 times a year, after 2 starter doses for adults with moderate to severe plaque psoriasis and for adults with active psoriatic arthritisAfter that, the dosing schedule is every 12 weeks. Each dose consists of one 150mg/mL injection beneath the skin. SKYRIZI is available as the SKYRIZI Pen or pre-filled syringe.

It can be taken in your doctor’s office or at home after you receive training from your healthcare provider. Talk to your doctor to see what choice is right for you.

What is the most important information I should know about SKYRIZI?

SKYRIZI may cause serious side effects, including serious allergic reactions. Stop using SKYRIZI and get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction:

  • fainting, dizziness, feeling lightheaded (low blood pressure)
  • swelling of face, eyelids, lips, mouth, tongue, or throat
  • trouble breathing or throat tightness
  • chest tightness
  • skin rash, hives
  • itching

SKYRIZI may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with SKYRIZI and may treat you for TB before you begin treatment with SKYRIZI if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with SKYRIZI. Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:

  • fever, sweats, or chills
  • cough
  • shortness of breath
  • blood in your mucus (phlegm)
  • muscle aches
  • warm, red, or painful skin or sores on your body different from your psoriasis
  • weight loss
  • diarrhea or stomach pain
  • burning when you urinate or urinating more often than normal

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the ingredients in SKYRIZI.

The most common side effects of SKYRIZI include:

Upper respiratory injection
Fatigue
Injection site reactions
Fungal skin infection
Headache

These are not all the possible side effects of SKYRIZI. Call your doctor for medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

Please see the Full Prescribing Information, including the Medication Guide, for SKYRIZI.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.