SKYRIZI infusion support

SUPER/VOICEOVER (V.O.):
UNDERSTANDING INFUSIONS

Please see Important Safety Information near the end of this video.

Please see link for the full Prescribing Information, including the Medication Guide, for SKYRIZI.

Talk to your doctor about lab tests before, during, and up to 12 weeks of treatment with SKYRIZI.

USE¹
SKYRIZI is a prescription medicine used to treat moderate to severe Crohn’s disease in adults.

SAFETY CONSIDERATIONS¹

SKYRIZI may cause serious side effects, including:

• Serious allergic reactions: Stop using SKYRIZI and get emergency medical help right away if you get any symptoms of a serious allergic reaction.
• Infections: SKYRIZI may increase your risk of infections. Before starting treatment, your doctor should check you for infections and tuberculosis. Tell your doctor right away if you have an infection or symptoms of one.

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the ingredients in SKYRIZI.

• Also, tell your doctor if you plan to or recently received a vaccine.

Please see Important Safety Information near the end of this video.

Please see link for the full Prescribing Information, including the Medication Guide, for SKYRIZI.

SKYRIZI may cause serious side effects, including:
Liver problems in Crohn’s disease: A person with Crohn’s disease who received SKYRIZI through a vein in the arm developed changes in liver blood tests with a rash that led to hospitalization. Your doctor will do liver blood tests before and during treatment and may stop treatment with SKYRIZI if you develop liver problems.

SUPER:
HARPER

Harper (V.O.):
Hi! I’m Harper.

Now that you’re taking an important step, you’ll be starting SKYRIZI with 3 infusions.

After your third infusion, you’ll move on to the second part of your treatment. You’ll learn all about that in a different video.

I'm here to make SURE you feel prepared for your infusions.

On-screen text:
SET YOURSELF UP BY PREPARING IN ADVANCE
UNDERSTAND THE INFUSION PROCESS
REMEMBER, THERE ARE HELPFUL RESOURCES AVAILABLE TO YOU
ENROLL IN SKYRIZI COMPLETE

IV = INTRAVENOUS

1.866.SKYRIZI
1.866.759.7494

Nurse Ambassadors are provided by AbbVie and do not work under the direction of your health care professional (HCP) or give medical advice. They are trained to direct patients to their HCP for treatment-related advice, including further referrals.

HARPER (V.O.):
By the end of this video, you'll know how to set yourself up by preparing as much as you can in advance and understand the infusion process.

Remember, there are helpful resources available to you. If you enroll in Skyrizi Complete you’ll get a Nurse Ambassador who’s dedicated to helping you every step of the way.

Call them any time you have questions about your treatment, and they’ll help make sure you’ve got everything handled.

Alright, let’s dive in.

SUPER:
WHAT IS AN INFUSION?

HARPER (V.O.):
SKYRIZI infusion therapy delivers a starter dose of medication to your bloodstream. Be sure to ask your infusion site how long your treatment will take. You’ll have 3 infusions, and they’ll be 4 weeks apart.

SUPER:
3 INFUSIONS,
1 EVERY 4 WEEKS

SUPER:
INFUSIONS CAN TAKE PLACE AT:
A HOSPITAL
A DOCTOR’S OFFICE
AN INFUSION CENTER

HARPER (V.O.):
Oh, and there are different kinds of places where you might get your infusion. Your doctor will let you know where you'll be getting yours.

SUPER/V.O.:
UNDERSTANDING INFUSIONS:

• You’ll have 3 infusions
• 1 every 4 weeks
• Talk to your doctor about your infusion
• Enroll in Skyrizi Compete
• Reach out to your Nurse Ambassador

HOW CAN I PREPARE AHEAD OF TIME FOR MY INFUSION DAYS?

HARPER (V.O.):
Scheduling your infusions in advance really helps you, so you can make sure you give yourself the time you need.

SUPER:
Cell phone screen: UNKNOWN CALLER

HARPER (V.O.):
It’s also good to keep an eye out for phone calls from numbers you don’t know. Because someone could be calling to confirm you’re all set to start treatment. And very important—the infusion staff will need to know what medications and supplements you currently take, so remember to make a list and take it with you.

Oh, and it helps to get a good night’s sleep before your infusion.

SUPER:
MAKE A LIST OF MEDICATIONS AND SUPPLEMENTS

SHOULD I BRING ANYTHING ELSE TO THE INFUSION SITE?

HARPER (V.O.):
The staff will also ask for your medical insurance card and ID, so have them ready.

If you have a Skyrizi Complete Savings Card, bring it with you.

You may want to bring something to keep you entertained, like a book or a tablet to catch up on your shows.

Ask your infusion location if there’s anything else you could bring. They might recommend bringing things like a water bottle or a pillow and blanket.

By the way, your infusion nurse will thank you for wearing something that gives them easy access to your arms...like this!

SUPER:
PILLOW & BLANKET
ENTERTAINMENT
WATER
WEAR COMFORTABLE CLOTHING

SUPER/V.O.
GETTING READY:

• Watch for unknown callers
• Make a list of medications and supplements
• Bring photo ID, insurance card, and Savings Card
• Wear short sleeves

WHAT WILL HAPPEN THE DAY OF?

HARPER (V.O.):
When you arrive at the infusion location for your treatment they will check your vital signs. Don’t worry, this is all part of the process.

Ask your infusion site how long your appointment will take.

SUPER:
IV = INTRAVENOUS

HARPER (V.O.):
The infusion nurse will set you up on an infusion chair with an IV and you'll be ready to start treatment.

By the way, you might want to go to the restroom before you start.

And typically, during the infusion, the nurses will check in to see how you’re doing.

SUPER:
WHAT HAPPENS AFTER THE INFUSION IS DONE?

SUPER:
LET YOUR INFUSION NURSE KNOW IF YOU EXPERIENCE ANY OF THE FOLLOWING:

• fainting, dizziness, feeling lightheaded (low blood pressure)
• swelling of your face, eyelids, lips, mouth, tongue or throat

Please see Medication Guide for list of additional possible side effects.

HARPER (V.O.):
Once your infusion is over, the nurse will ask you to stay for a bit to monitor you.

They’ll also explain a few things to watch out for.

Definitely let them know if you feel anything unusual.

As soon as they give you the OK, you’re good to go until your next infusion.

SUPER:
LET YOUR INFUSION NURSE KNOW IF YOU FEEL ANYTHING UNUSUAL

LET YOUR INFUSION NURSE KNOW IF YOU EXPERIENCE ANY OF THE FOLLOWING:

• trouble breathing or throat tightness
• skin rash, hives
• chest tightness
• itching

Please see Medication Guide for list of additional possible side effects.

SUPER/V.O.:
INFUSION TREATMENT:

• Ask your infusion site how long the appointment will take
• Use the restroom before you start
• Call your infusion nurse if you feel anything unusual during or after the infusion

SUPER:
LET’S REVIEW

SET YOURSELF UP BY PREPARING IN ADVANCE

UNDERSTAND THE INFUSION PROCESS

IV = INTRAVENOUS

REMEMBER, THERE ARE HELPFUL RESOURCES AVAILABLE TO YOU

ENROLL IN SKYRIZI COMPLETE

HARPER (V.O.):
OK, so let’s review:

Set yourself up by preparing as much as you can in advance

Understand the infusion process and reach out to your doctor’s office if you have questions

Remember, there are helpful resources available to you

Enroll in Skyrizi Complete for ongoing support. You’ll have access to insurance and financial support.

SUPER:
SKYRIZI COMPLETE NURSE AMBASSADORS:

• Dedicated 1-to-1 support
• Injection training
• Educational resources

1.866.SKYRIZI
1.866.759.7494

HARPER (V.O.):
Plus, a dedicated Nurse Ambassador who can help you access additional resources.

Enroll right here on SKYRIZI.com/signup.

Just ask your doctor or call 1.866.SKYRIZI.

Hopefully I’ve helped get rid of some infusion confusion.

You’ve got this!

SUPER/V.O.:
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about SKYRIZI^® (risankizumab-rzaa)?

SKYRIZI is a prescription medicine that may cause serious side effects, including:

Serious allergic reactions:

• Stop using SKYRIZI and get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction:
  — fainting, dizziness, feeling lightheaded (low blood pressure)
  — swelling of your face, eyelids, lips, mouth, tongue, or throat
  — trouble breathing or throat tightness
  — chest tightness
  — skin rash, hives
  — itching

Infections:
SKYRIZI may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with SKYRIZI and may treat you for TB before you begin treatment with SKYRIZI if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with SKYRIZI.

• Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including::
  — fever, sweats, or chills
  — cough
  — shortness of breath
  — blood in your mucus (phlegm)
  — muscle aches
  — warm, red, or painful skin or sores on your body different from your psoriasis
  — weight loss
  — diarrhea or stomach pain
  — burning when you urinate or urinating more often than normal
  

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the ingredients in SKYRIZI. See the Medication Guide or Consumer Brief Summary for a complete list of ingredients.

Before using SKYRIZI, tell your healthcare provider about all of your medical conditions, including if you:

• have any of the conditions or symptoms listed in the section “What is the most important information I should know about SKYRIZI?”
• have an infection that does not go away or that keeps coming back.
• have TB or have been in close contact with someone with TB.
• have recently received or are scheduled to receive an immunization (vaccine). Medicines that interact with the immune system may increase your risk of getting an infection after receiving live vaccines. You should avoid receiving live vaccines right before, during, or right after treatment with SKYRIZI. Tell your healthcare provider that you are taking SKYRIZI before receiving a vaccine.
• are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes into your breast milk.
• become pregnant while taking SKYRIZI. You are encouraged to enroll in the Pregnancy Registry, which is used to collect information about the health of you and your baby. Talk to your healthcare provider or call 1-877-302-2161 to enroll in this registry.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of SKYRIZI?
SKYRIZI may cause serious side effects. See “What is the most important information I should know about SKYRIZI?”

Liver problems in Crohn’s disease: A person with Crohn’s disease who received SKYRIZI through a vein in the arm developed changes in liver blood tests with a rash that led to hospitalization. Your healthcare provider will do blood tests to check your liver before, during, and up to 12 weeks of treatment and may stop treatment with SKYRIZI if you develop liver problems. Tell your healthcare provider right away if you notice any of the following symptoms: unexplained rash, nausea, vomiting, stomach (abdominal) pain, tiredness (fatigue), loss of appetite, yellowing of the skin and eyes (jaundice), and dark urine.

The most common side effects of SKYRIZI in people treated for Crohn’s disease include: upper respiratory infections, headache, joint pain, stomach (abdominal) pain, injection site reactions, low red blood cells (anemia), fever, back pain, and urinary tract infection.

These are not all the possible side effects of SKYRIZI. Call your doctor for medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

SKYRIZI is available in a 600 mg/10 mL vial for intravenous infusion and a 180 mg/1.2 mL or 360 mg/2.4 mL single-dose prefilled cartridge with on-body injector.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

SUPER:
Reference: 1. SKYRIZI [package insert]. North Chicago, IL: AbbVie Inc.

Please see link for the full Prescribing Information, including the Medication Guide, for SKYRIZI.

SKYRIZI logo]
[Skyrizi Complete logo]

[AbbVie logo]
© 2023 AbbVie. All rights reserved. SKYRIZI^® and its design are registered trademarks of AbbVie Biotechnology Ltd.

US-SKZG-230139

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