Endoscopic Improvement Video Transcript

SKYRIZI® (risankizumab-rzaa)
SUPER GRAPHIC: WHAT IS ENDOSCOPIC IMPROVEMENT?

VO: Hi, I’m Michelle, and I have moderate to severe Crohn’s disease.
SUPER GRAPHIC: That’s me
SUPER: Not an actual patient

VO: My Crohn's symptoms, including abdominal pain and frequent trips to the bathroom, are really disruptive. 
SUPER GRAPHIC: abdominal pain frequent trips to the bathroom

VO: I thought the only goals for treating my Crohn’s were symptom relief and remission.
SUPER GRAPHIC: My treatment goals:
• symptom relief
• clinical remission

VO: But recently, my gastroenterologist and I discussed that there's another important Crohn’s treatment goal: endoscopic improvement.
SUPER GRAPHIC: My gastroenterologist
My treatment goals:
• symptom relief
• clinical remission
• endoscopic improvement

VO: He explained that endoscopic improvement means a visible improvement of the intestinal lining.

SUPER GRAPHIC: Endoscopic Improvement means a visible improvement of the intestinal lining

VO: And that monitoring changes in the intestinal lining over time with an endoscopy is another important part of managing Crohn’s.
SUPER GRAPHIC: An endoscopy (such as a colonoscopy) is a non-surgical procedure to view the digestive tract. 

VO: That's because even if you’re feeling better, damaging inflammation can still be happening there.
SUPER GRAPHIC: Inflammation could be damaging the intestinal lining even if you're feeling better

VO: During my last visit, my doctor told me about a treatment option for Crohn's called SKYRIZI.
SUPER: SKYRIZI is a prescription medicine used to treat moderate to severe Crohn’s disease in adults. Please continue watching for Important Safety Information. Please see link for the full Prescribing Information, including the Medication Guide, for SKYRIZI.

VO:  He said SKYRIZI can help me achieve treatment goals for Crohn's: symptom relief, remission, and endoscopic improvement—which means at least a 50% visible improvement of the intestinal lining.

SUPER GRAPHIC: SKYRIZI can help achieve these key Crohn's treatment goals:
 - symptom relief
 - clinical remission
 - endoscopic improvement

SKYRIZI is a prescription medicine used to treat moderate to severe Crohn’s disease in adults. Please continue watching for Important Safety Information. Please see link for the full Prescribing Information, including the Medication Guide, for SKYRIZI.

VO: I'm ready to take control of my Crohn's. After talking to my doctor, I'm going to try SKYRIZI.
SUPER GRAPHIC: I'm going to try SKYRIZI
SKYRIZI logo

VO/SUPER:

USE AND IMPORTANT SAFETY INFORMATION

SKYRIZI® (risankizumab-rzaa) USE

SKYRIZI is a prescription medicine used to treat moderate to severe Crohn’s disease in adults.


IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SKYRIZI® (risankizumab-rzaa)?

SKYRIZI is a prescription medicine that may cause serious side effects, including:

Serious allergic reactions:

• Stop using SKYRIZI and get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction:

– fainting, dizziness, feeling lightheaded (low blood pressure)
– swelling of your face, eyelids, lips, mouth, tongue, or throat
– trouble breathing or throat tightness
– chest tightness
– skin rash, hives
– itching

Infections:
SKYRIZI may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with SKYRIZI and may treat you for TB before you begin treatment with SKYRIZI if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with SKYRIZI.

• Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:

– fever, sweats, or chills
– cough
– hortness of breath
– blood in your mucus (phlegm)
– muscles aches
– warm, red, or painful skin or sores on your body different from your psoriasis
– weight loss
– diarrhea or stomach pain
– burning when you urinate or urinating more often than normal

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the ingredients in SKYRIZI. See the Medication Guide or Consumer Brief Summary for a complete list of ingredients.

Before using SKYRIZI, tell your healthcare provider about all of your medical conditions, including if you:

• have any of the conditions or symptoms listed in the section “What is the most important information I should know about SKYRIZI?”

• have an infection that does not go away or that keeps coming back.

• have TB or have been in close contact with someone with TB.

• have recently received or are scheduled to receive an immunization (vaccine). Medicines that interact with the immune system may increase your risk of getting an infection after receiving live vaccines. You should avoid receiving live vaccines right before, during, or right after treatment with SKYRIZI. Tell your healthcare provider that you are taking SKYRIZI before receiving a vaccine.

• are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm your unborn baby.

• are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes into your breast milk.

• become pregnant while taking SKYRIZI. You are encouraged to enroll in the Pregnancy Registry, which is used to collect information about the health of you and your baby. Talk to your healthcare provider or call 1-877-302-2161 to enroll in this registry.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of SKYRIZI?

SKYRIZI may cause serious side effects. See “What is the most important information I should know about SKYRIZI?”

Liver problems in Crohn’s disease: A person with Crohn’s disease who received SKYRIZI through a vein in the arm developed changes in liver blood tests with a rash that led to hospitalization. Your healthcare provider will do blood tests to check your liver before, during, and up to 12 weeks of treatment and may stop treatment with SKYRIZI if you develop liver problems. Tell your healthcare provider right away if you notice any of the following symptoms: unexplained rash, nausea, vomiting, stomach (abdominal) pain, tiredness (fatigue), loss of appetite, yellowing of the skin and eyes (jaundice), and dark urine.

The most common side effects of SKYRIZI in people treated for Crohn’s disease include: upper respiratory infections, headache, joint pain, stomach (abdominal) pain, injection site reactions, low red blood cells (anemia), fever, back pain, and urinary tract infection.

These are not all the possible side effects of SKYRIZI. Call your doctor for medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

SKYRIZI is available in a 600 mg/10 mL vial for intravenous infusion and a 180 mg/1.2 mL or 360 mg/2.4 mL single-dose prefilled cartridge with on-body injector.

Please see the full Prescribing Information, including the Medication Guide, for SKYRIZI.

SUPER ONLY:
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

 

© 2022 AbbVie. All rights reserved. SKYRIZI® and its design are registered trademarks of AbbVie Biotechnology Ltd.

US-SKZG-220255 December 2022

SUPER GRAPHIC: SKYRIZI logo

Talk to your doctor about SKYRIZI.