JONATHAN,
a SKYRIZI Crohn’s Patient, Shares His Experience
SKYRIZI RESULTS
Take Control of Crohn's With RELIEF, REMISSION, and REPAIR*
SKYRIZI can help deliver significant symptom relief, remission, and visible repair* of intestinal lining damage.
*Areas visually assessed may not represent total resolution or repair of the entire intestinal lining or deeper bowel layers. Visible repair is defined as at least a 50% improvement of the intestinal lining.
AS EARLY AS 4 WEEKS
RELIEF
In trials starting with IV† dosing‡
Significant symptom RELIEF
including:
Less abdominal pain
Fewer bowel movements
REMISSION meaning few to no symptoms
AT 12 WEEKS
REMISSION & REPAIR
Results from a trial
starting with SC§ dosing||
56%REMISSION
People who achieved remission,
meaning few to no symptoms Four 720 mg SC§ starter injections
43%REPAIR*
People who achieved visible
repair of intestinal lining damage Four 720 mg SC§ starter injections
Results from two trials
starting with IV† dosing‡
44% achieved REMISSION 600 mg IV† starter infusions
36% achieved visible REPAIR*
of intestinal lining damage 600 mg IV† starter infusions
*Areas visually assessed may not represent total resolution or repair of the entire intestinal lining or deeper bowel layers. Visible repair is defined as at least a 50% improvement of the intestinal lining.
AT 1 YEAR¶
REMISSION & REPAIR
Results from a maintenance trial starting with IV dosing in eligible patients#
61%REMISSION
People who achieved remission,
meaning few to no symptoms 180 mg SC§ maintenance injection
57% achieved REMISSION 360 mg SC§ maintenance injection
50%REPAIR*
People who achieved visible
repair of intestinal lining damage 180 mg SC§ maintenance injection
48% achieved visible REPAIR*
of intestinal lining damage 360 mg SC§ maintenance injection
Your doctor will decide what maintenance dose is right for you.
*Areas visually assessed may not represent total resolution or repair of the entire intestinal lining or deeper bowel layers. Visible repair is defined as at least a 50% improvement of the intestinal lining.
¶Results at 1 year measured in SKYRIZI patients who met clinical response at 12 weeks.
AT 5 YEARS**
REMISSION & REPAIR
Results from another trial starting with IV† dosing
**In the less strict study at 5 years, everyone knew SKYRIZI was used, which may have influenced results. Results at 1 and 5 years measured in SKYRIZI patients who met clinical response at 12 weeks.
*Areas visually assessed may not represent total resolution or repair of the entire intestinal lining or deeper bowel layers. Visible repair is defined as at least a 50% improvement of the intestinal lining.
Individual results may vary.
†Intravenous infusion (through a vein in the arm).
‡Results are combined from 2 IV induction clinical trials of 527 patients: one included patients with or without prior biologic failure and the other included patients with prior biologic failure.
§Subcutaneous injection (under the skin).
||Results from a trial of 180 patients who started with SKYRIZI 720 mg SC doses.
#Results from 252 patients who achieved clinical response defined as a reduction in CDAI of at least 100 points from baseline after 12 weeks of treatment with SKYRIZI in IV induction clinical trials.
See REAL IMAGES Below
Click to compare
Real clinical trial endoscopy images from a bio-naive patient who received SKYRIZI 600 mg through a vein (IV) during induction and 180 mg subcutaneous through the skin during maintenance. Based on endoscopy, patient saw visible improvement of intestinal lining damage at 12 weeks and 1 year.
In clinical trials, some people on SKYRIZI saw little to no evidence of active Crohn's of the intestinal lining at 12 weeks and at 1 year. In the maintenance trial, this measure was not tested for a difference between SKYRIZI and placebo at 1 year. Results at 1 year measured among those who were eligible and entered a maintenance trial.# All results are based on areas that were assessed on endoscopy.
Individual results may vary.
With SKYRIZI,
I ACHIEVED REMISSION
AT 1 YEAR. It was a fantastic feeling.
I ACHIEVED REMISSION
AT 1 YEAR. It was a fantastic feeling.
IMPORTANT SAFETY INFORMATION
SKYRIZI may cause serious side effects, including:
Serious allergic reactions. Stop using SKYRIZI and get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction:
- fainting, dizziness, feeling lightheaded (low blood pressure)
- swelling of your face, eyelids, lips, mouth, tongue, or throat
- trouble breathing or throat tightness
- chest tightness
- skin rash, hives
- itching
Infections. SKYRIZI may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider may check you for infections and tuberculosis (TB) before starting treatment with SKYRIZI and may treat you for TB before you begin treatment with SKYRIZI if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with SKYRIZI.
Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:
- fever, sweats, or chills
- cough
- shortness of breath
- blood in your mucus (phlegm)
- muscle aches
- warm, red, or painful skin or sores on your body different from your psoriasis
- weight loss
- diarrhea or stomach pain
- burning when you urinate or urinating more often than normal
Liver problems. A person with Crohn's disease who received SKYRIZI through a vein in the arm developed changes in liver blood tests with a rash that led to hospitalization. Your healthcare provider will do blood tests to check your liver before, during, and at least up to 12 weeks of treatment, and may stop treatment with SKYRIZI if you develop liver problems. Tell your healthcare provider right away if you notice any of the following symptoms: unexplained rash, nausea, vomiting, stomach (abdominal) pain, tiredness (fatigue), loss of appetite, yellowing of the skin and eyes (jaundice), and dark urine.
These are not all the possible side effects of SKYRIZI.
See Important Safety Information and Medication Guide at the bottom of the screen.
Discuss with your doctor to see if SKYRIZI is appropriate for you.
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