WHAT IS
CROHN’S
DISEASE?
Understanding Crohn’s Disease
Crohn’s disease is a chronic (long-term) disease that causes inflammation in your gastrointestinal (GI) tract. It can affect any part of the GI tract from mouth to anus. Crohn’s is a progressive disease, meaning it can get worse over time. It’s important that your treatment goals include both remission and endoscopic improvement.
Crohn’s belongs to a larger group of conditions known as inflammatory bowel disease, or IBD. According to the National Institute of Health, it’s estimated that more than half a million people live with Crohn’s disease in the United States, so chances are you or someone you know has been diagnosed.
The exact causes of Crohn’s disease aren’t fully known, but research suggests that genetics, the environment, or an overactive immune system contribute to it.
Inflammation and Crohn’s Disease
Inflammation is your body’s normal response to protect you against something your immune system thinks will cause harm.
When inflammation caused by your immune system doesn’t go away, it can cause conditions like Crohn’s disease.
Crohn’s Disease Symptoms
Symptoms can range from mild to severe, depending on the severity and location of the inflammation.
The most common symptoms of Crohn’s disease caused by inflammation are:
- Diarrhea
- Cramping
- Abdominal pain
- Weight loss
- Fatigue
Sometimes symptoms can come on suddenly, without warning. This is called a flare-up.
The opposite is also true, in which you may experience times with few or no symptoms, also known as remission.
The key goals for Crohn’s disease treatment are to help you achieve symptom relief, endoscopic improvement, and maintain remission.
Types of Treatment
There are different types of treatment options depending on your symptoms and level of severity. Conventional treatments can include the use of medication, changes in diet and nutrition, and, sometimes surgical procedures to repair or remove affected parts of your GI tract. Biologics work by targeting specific parts of the immune system that may contribute to the inflammation seen in Crohn’s.
Be sure to talk to your doctor about the benefits and risks of all available treatments and what treatment option may be right for you.
Common treatments for Crohn’s disease include:
A BIOLOGIC
FOR Crohn’s
DISEASE
SKYRIZI is the first treatment for Crohn’s that works differently by specifically targeting the interleukin-23 (IL-23) protein, which is one of the key proteins responsible for inflammation. By targeting IL-23, SKYRIZI can help reduce the excess inflammation that may contribute to Crohn’s symptoms.
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