How SKYRIZI (risankizumab-rzaa) Works
Voice Over (V.O.):
Balance is important. You can see that in nature in how plants and animals depend on one another.
Balance is important inside your body, too. One of the ways your immune system protects you is with inflammation. But too much inflammation can mean your immune system is overactive. That’s what happens with psoriatic arthritis. Joint pain, stiffness, and swelling are actually symptoms of an imbalance inside your body.
While the exact cause of psoriatic arthritis is unknown, your body may be producing too much of a protein called IL-23. IL-23 is one of several proteins that may contribute to excess inflammation inside the body, which can lead to thick, red, scaly plaques on the skin and joint pain, stiffness, and swelling.
For adults with active psoriatic arthritis, this is where SKYRIZI comes in. SKYRIZI is a type of immune protein similar to other proteins produced by your own body. It works by binding to excess IL-23. This can help reduce the inflammation that leads to pain in the joints and plaques on the skin.
That’s how reducing inflammation inside can make a difference. Now that you’ve seen how SKYRIZI can work, ask your dermatologist if SKYRIZI could be right for you.
USE AND IMPORTANT SAFETY INFORMATION
SKYRIZI® (risankizumab-rzaa) USE
SKYRIZI is a prescription medicine used to treat adults with active psoriatic arthritis (PsA).
SKYRIZI may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with SKYRIZI and may treat you for TB before you begin treatment with SKYRIZI if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with SKYRIZI.
- Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:
- fever, sweats, or chills
- shortness of breath
- blood in your mucus (phlegm)
- muscle aches
- warm, red, or painful skin or sores on your body different from your psoriasis
- weight loss
- diarrhea or stomach pain
- burning when you urinate or urinating more often than normal
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of SKYRIZI?
SKYRIZI may cause serious side effects. See “What is the most important information I should know about SKYRIZI?”
The most common side effects of SKYRIZI include upper respiratory infections, feeling tired, fungal skin infections, headache, and injection site reactions.
These are not all the possible side effects of SKYRIZI. Call your doctor for medical advice about side effects.
Use SKYRIZI exactly as your healthcare provider tells you to use it.
SKYRIZI is available in a 150 mg/mL prefilled syringe and pen.
Please see the Full Prescribing Information, including the Medication Guide, for SKYRIZI.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie may be able to help.
Visit AbbVie.com/myAbbVieAssist to learn more.
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