How SKYRIZI Works

The science behind SKYRIZI

How does SKYRIZI work?

Psoriatic arthritis (PsA) starts inside your body. While the exact cause is unknown, an overactive immune system could be a source.

SKYRIZI is designed to work with your immune system, attaching to a specific protein that can cause inflammation. By attaching to this protein, SKYRIZI helps reduce excess inflammation inside the body that leads to pain, stiffness, and swelling in the joints.

SKYRIZI works in the immune system

SKYRIZI is a biologic designed to be similar to proteins found within your own immune system. It specifically attaches to a protein called interleukin-23 (IL-23), one of the proteins that may contribute to excess inflammation, which can contribute to joint pain, stiffness, and swelling associated with PsA.

The good and bad of inflammation

One of the ways your immune system protects you is with inflammation. However, too much inflammation can mean your immune system is overactive, which can contribute to signs and symptoms associated with PsA.

IL-23 protein

A protein imbalance

While the exact cause of psoriatic arthritis is unknown, your body may produce too much of a protein called IL-23. IL-23 is one of several proteins that may contribute to excess inflammation inside your body, which can contribute to joint pain, stiffness, and swelling associated with PsA.

SKYRIZI targeting IL-23 protein

What SKYRIZI does

This is where SKYRIZI comes in. SKYRIZI works by attaching to excess IL-23 proteins. This can help reduce the inflammation inside the body, which can contribute to joint pain, stiffness, and swelling associated with PsA. 

Now that you know the science behind SKYRIZI, see the results.