JONATHAN: Hi, I'm Jonathan, and I'm going to talk about my experience taking SKYRIZI.

SUPER: JONATHAN
A REAL CROHN’S PATIENT TAKING SKYRIZI SINCE 2023

GRAPHIC: SKYRIZI Logo

LEGAL SUPER: SKYRIZI is a prescription medicine used to treat moderate to severe Crohn’s disease in adults.

LEGAL SUPER: Please see Important Safety Information near the end of this video.

JONATHAN: So, between the infusion center and then my doctor that prescribed the medicine, they were very helpful in teaching me about treatment.

JONATHAN: When I arrived on the day of, the team at the infusion center, you know, put me at ease.

JONATHAN: It ended up being kind of like, you know, where I could just check out, and get the treatment, and ignore the rest of the world.

JONATHAN: I heard from the Skyrizi Complete Nurse Ambassador prior to even infusion number one.

LEGAL SUPER: Nurse Ambassadors are provided by AbbVie and do not work under the direction of your health care professional (HCP) or give medical advice. They are trained to direct patients to their HCP for treatment-related advice, including further referrals.

JONATHAN: The Nurse Ambassador, you know, first and foremost, she was just so great and so supportive.

LEGAL SUPER: Nurse Ambassadors are provided by AbbVie and do not work under the direction of your health care professional (HCP) or give medical advice. They are trained to direct patients to their HCP for treatment-related advice, including further referrals.

JONATHAN: It really helped the transition to, one, just start taking a medication like SKYRIZI.

JONATHAN: One of the first things I remember she promised me, she goes, “You know, I know you have the three infusions ahead of you.”

LEGAL SUPER: Start SKYRIZI with 3 infusions administered by a healthcare provider.

JONATHAN: “As soon as you start the OBI at home, I’m gonna be there for you. I’m gonna come to your house.”

JONATHAN: And sure enough, she was there. To help guide me through it.

JONATHAN: My healthcare professional taught me to use the SKYRIZI On-Body Injector.

LEGAL SUPER: You can administer SKYRIZI OBI at home after being trained by a healthcare professional.

JONATHAN: My experience with the On-Body Injector, the OBI, has been pretty good.

LEGAL SUPER: Read the SKYRIZI Instructions for Use for the full set of detailed instructions on the preparation and administration of SKYRIZI.

JONATHAN: It’s really something I only have to think about every few months in your calendar to do it. And it’s straightforward to me.

LEGAL SUPER: After 3 starter doses, SKYRIZI maintenance dosing is given every 8 weeks.

JONATHAN: After about the second or third time doing it, it becomes second nature to me.

SUPER: It becomes SECOND NATURE TO ME

LEGAL SUPER: Read the SKYRIZI Instructions for Use for the full set of detailed instructions on the preparation and administration of SKYRIZI.

JONATHAN: For someone starting out and it being your first time, you’re gonna have a lot of questions and that’s OK. You know, ask away.

JONATHAN: Knowing that it’s the first step to feeling better and reducing symptoms, it’s something you need to hold on to.

LEGAL SUPER: In clinical trials, SKYRIZI helped achieve significant symptom relief, including less abdominal pain and fewer bowel movements in as few as 4 weeks.

JONATHAN: With the treatment that I’ve gotten from SKYRIZI, I feel more in control because I’m feeling better. I’m not having the symptoms.

SUPER: I feel more IN CONTROL

LEGAL SUPER: In clinical trials, SKYRIZI helped achieve significant symptom relief as early as 4 weeks.

JONATHAN: So, those things that were out of my control, like traveling, going out to eat, and socializing with friends, are back in my control.

LEGAL SUPER: In clinical trials, SKYRIZI helped achieve significant symptom relief, including less abdominal pain and fewer bowel movements as few as 4 weeks.

JONATHAN: The word I would use is empowering.

GRAPHIC: SKYRIZI Logo

LEGAL SUPER: Please keep watching for Important Safety Information.

VO/SUPER:

USE AND IMPORTANT SAFETY INFORMATION

SKYRIZI® (risankizumab-rzaa) USE
SKYRIZI is a prescription medicine used to treat moderate to severe Crohn’s disease in adults.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about SKYRIZI® (risankizumab-rzaa)?

SKYRIZI is a prescription medicine that may cause serious side effects, including:

Serious allergic reactions:

• Stop using SKYRIZI and get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction:
  • fainting, dizziness, feeling lightheaded (low blood pressure)
  • swelling of your face, eyelids, lips, mouth, tongue, or throat
  • trouble breathing or throat tightness
  • chest tightness
  • skin rash, hives
  • itching

Infections:

SKYRIZI may lower the ability of your immune system to fight infections and may increase your risk of infections. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with SKYRIZI and may treat you for TB before you begin treatment with SKYRIZI if you have a history of TB or have active TB. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with SKYRIZI.

• Tell your healthcare provider right away if you have an infection or have symptoms of an infection, including:
  • fever, sweats, or chills
  • cough
  • shortness of breath
  • blood in your mucus (phlegm)
  • muscle aches
  • warm, red, or painful skin or sores on your body different from your psoriasis
  • weight loss
  • diarrhea or stomach pain
  • burning when you urinate or urinating more often than normal

Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the ingredients in SKYRIZI. See the Medication Guide or Consumer Brief Summary for a complete list of ingredients.

Before using SKYRIZI, tell your healthcare provider about all of your medical conditions, including if you:

• have any of the conditions or symptoms listed in the section “What is the most important information I should know about SKYRIZI?”
• have an infection that does not go away or that keeps coming back.
• have TB or have been in close contact with someone with TB.
• have recently received or are scheduled to receive an immunization (vaccine). Medicines that interact with the immune system may increase your risk of getting an infection after receiving live vaccines. You should avoid receiving live vaccines right before, during, or right after treatment with SKYRIZI. Tell your healthcare provider that you are taking SKYRIZI before receiving a vaccine.
• are pregnant or plan to become pregnant. It is not known if SKYRIZI can harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if SKYRIZI passes into your breast milk.
• become pregnant while taking SKYRIZI. You are encouraged to enroll in the Pregnancy Registry, which is used to collect information about the health of you and your baby. Talk to your healthcare provider or call 1-877-302-2161 to enroll in this registry.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of SKYRIZI?

SKYRIZI may cause serious side effects. See "What is the most important information I should know about SKYRIZI?”

Liver problems may happen while being treated for Crohn’s disease or ulcerative colitis: A person with Crohn’s disease who received SKYRIZI through a vein in the arm developed changes in liver blood tests with a rash that led to hospitalization. Your healthcare provider will do blood tests to check your liver before, during, and at least up to 12 weeks of treatment, and may stop treatment with SKYRIZI if you develop liver problems. Tell your healthcare provider right away if you notice any of the following symptoms: unexplained rash, nausea, vomiting, stomach (abdominal) pain, tiredness (fatigue), loss of appetite, yellowing of the skin and eyes (jaundice), and dark urine.

The most common side effects of SKYRIZI in people treated for Crohn’s disease and ulcerative colitis include: upper respiratory infections, headache, joint pain, stomach (abdominal) pain, injection site reactions, low red blood cells (anemia), fever, back pain, urinary tract infection, and rash.

These are not all the possible side effects of SKYRIZI. Call your doctor for medical advice about side effects.

Use SKYRIZI exactly as your healthcare provider tells you to use it.

SKYRIZI (risankizumab-rzaa) is available in a 600 mg/10 mL vial for intravenous infusion and a 180 mg/1.2 mL or 360 mg/2.4 mL single-dose prefilled cartridge with on-body injector.

Please see the Full Prescribing Information, including the Medication Guide, for SKYRIZI.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

© 2025 AbbVie. All rights reserved.

SKYRIZI® and its design are registered trademarks of AbbVie Biotechnology Ltd.

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